The record
Written from the 1 report below. Nothing here is unsourced.
- Indian researchers have produced the first comprehensive molecular profile of the venom gland of Stegodyphus sarasinorum, a socially living spider found across the subcontinent.
- Using a multi-omics approach combining transcriptomics, proteomics, metabolomics and Confocal Raman Spectroscopy, they identified dozens of proteins and 81 metabolites, including compounds linked to anti-cancer, antimicrobial and immune functions.
- In laboratory tests, venom gland extracts killed Dalton's Lymphoma Ascites cancer cells in a dose-dependent manner, and the team found protein families such as hemocyanins and lycotoxins already known for biomedical relevance.
- The researchers stress this is early-stage work and extensive validation, including animal studies and clinical trials, would be needed before any clinical use.
What to watch next
- Further validation studies in additional cancer models, healthy cells and animals
- Development of antimicrobial peptides or targeted anti-cancer compounds based on the identified lycotoxins
- Any follow-up research on hemocyanin proteins for cancer immunotherapy applications
Coverage1
1 report
English national1
All filed from India
Named India · United Arab Emirates · Ajay Kumar · Ajman University · Calicut University · GITAM University · PSG Institute of Advanced Studies · Springer Nature · Sree Neelakanta Government Sanskrit College · Stegodyphus sarasinorum · St. Joseph’s College, Devagiri · Veena Venugopal
The 1 report is listed beside the record.
Ask this story
Answers cite the reports above, or say they can't.