The record
Written by software from the 1 report below. The points restate them; where one says why it matters, that is Prism's reading, not a reported fact.
- A new review indicates that drug-delivery systems tested in young, healthy brains may not function effectively in older individuals due to age-related brain changes.
- Factors such as stiffened blood vessels, reduced blood flow, and impaired waste-clearance systems can impede the distribution of nanoparticle-based medicines.
- Researchers call for the development of age-responsive delivery systems and improved preclinical testing protocols.
- These advancements could help in developing better treatments for neurological conditions like Alzheimer's and Parkinson's disease.
What to watch next
- Development of age-responsive nanoparticle drug-delivery systems.
- Integration of age-specific assessment protocols in preclinical drug testing.
Who said what1
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Rajeev Taliyan
researcher of the Neuropsychopharmacology Division
1 quote · 1 outlet
“Crossing the blood-brain barrier is only the first step in delivering medicines to the brain. As we age, the brain undergoes several changes that can affect how a medicine reaches its target and how well it works”
In the article
…authors of the review, along with researchers from Taipei Medical University and affiliated institutions in Taiwan. The other authors are Ruei-Dun Teng, Jui-Ming Sun, Ting-Lin Yen, Cheng-Ta Hsieh and Chih-Hao Yang. “ Crossing the blood-brain barrier is only the first step in delivering medicines to the brain. As we age, the brain undergoes several changes that can affect how a medicine reaches its target and how well it works ,” Dr Taliyan said. The blood-brain barrier acts as a protective filter between the bloodstream and brain, making it difficult for many medicines to enter. But the review says the challenge continues even after a…
Coverage1
All filed from India
Named India · Taiwan · Ageing Research Reviews · BITS Pilani · Cheng-Ta Hsieh · Chih-Hao Yang · Jui-Ming Sun · Rajeev Taliyan · Ruei-Dun Teng · Taipei Medical University · Ting-Lin Yen
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