The record
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- Scientists are developing a non-animal method for testing inhalation toxicity of surfactants using laboratory-grown human airway tissues.
- This new approach aims to replace traditional animal testing methods that often struggle to accurately predict human respiratory reactions.
- The international project involves laboratories in India, the United States, the United Kingdom, and Switzerland.
- Successful validation of this method could lead to its formal adoption as a global regulatory standard.
What to watch next
- Drafting of the validation report for the OECD
- Submission of the peer-reviewed report to the OECD
- Long-term OECD evaluation process for final test guideline adoption
Who said what2
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Ankita Pandey
PETA India Science Policy Advisor
2 quotes · 1 outlet
“The traditional way of inhalation (tests) is exposing rats ...to that chemical and then ...depending upon whether it is a short study or a long term study, they are exposed to that chemical and then they kill the animal to see where it went in the lungs”
In the article
…models to assess point-of-contact respiratory toxicity of surfactants and derive human equivalent concentrations after single dose exposure,” was published in Toxicological Sciences, the animal welfare group said. “ The traditional way of inhalation (tests) is exposing rats ...to that chemical and then ...depending upon whether it is a short study or a long term study, they are exposed to that chemical and then they kill the animal to see where it went in the lungs ,” Dr Ankita Pandey, PETA India Science Policy Advisor, told businessline. “Anatomical and physiological differences between human and rat respiratory tracts limit the ability of rats to reliably predict how inhaled…
“We are currently analysing data from the study. The next step is to draft a validation report summarising the study’s findings for submission to the OECD”
In the article
…replacing animal testing with more modern and ethical approaches,” she said, adding that surfactants are commonly used pharmaceutical excipients that improve drug solubility, stability, absorption, and delivery. “ We are currently analysing data from the study. The next step is to draft a validation report summarising the study’s findings for submission to the OECD ,” the Peta representative said, of a process that included convening an independent panel of experts to review the report, and submit the peer-reviewed document to the OECD for consideration. “The formal process from…
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Named India · United States · Belgium · United Kingdom · Switzerland · Gujarat · Ankita Pandey · Environmental Protection Agency · Flemish Institute for Technological Research · Organisation for Economic Co-operation and Development · PETA India · PETA Science Consortium International
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