The record
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- Scientists transplanted human cortical organoids into newborn mice that were genetically engineered to have reduced brain development.
- The human tissue grew to account for a significant portion of the mice's cortical volume.
- These mice performed better on memory tests compared to mice without the human grafts.
- This experimental model provides a new method for investigating human brain development and potential treatments for neurological disorders.
What to watch next
- Ethical considerations regarding future experiments in non-human primates
- Assessment of how further maturation of human tissue affects animal behavior
- Additional studies to isolate specific behaviors dependent on human nerve cells
Who said what1
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Sergiu Pașca
1 quote · 1 outlet
“repeating this experiment in a primate would cross a clear red line for him”
In the article
…They will need to assess how those changes affect the animal. We also have to consider the ethics of inserting human brain tissue into animals more closely related to us. Pașca told MIT Technology Review that repeating this experiment in a primate would cross a clear red line for him . A more closely related animal, such as a monkey, might integrate human nerve cells in ways a mouse cannot, raising harder questions about its mental abilities and welfare. Anirban Mahapatra is a microbiologist,…
Coverage1
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Named United States · Anirban Mahapatra · Madeline Lancaster · MIT Technology Review · Nature · Sergiu Pașca · Shinya Yamanaka · Stanford
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